How Long Does It Take for Xeomin to Work?

Key Takeaways:

  • Xeomin injections start showing results within 3-4 days after treatment.
  • Patients may notice wrinkles fading within 3-4 days, with full effects in 30 days.
  • Xeomin works faster than Botox, taking effect in just 4 days.
  • Individual experiences can vary in onset of results.
  • Factors like dosage, injection sites, metabolism affect how quickly it works.
  • Areas like frown lines, crow's feet show faster effects.
  • Repeated treatments lead to faster results.
  • Proper aftercare ensures optimized outcome.


Xeomin is an injectable treatment used for improving the appearance of moderate to severe frown lines, crow's feet, and forehead wrinkles in adults. It contains incobotulinumtoxinA, a purified neurotoxin that works by temporarily blocking signals between nerves and muscles, resulting in weakened muscles that smooth out wrinkles and creases1.

This article will comprehensively evaluate and analyze how quickly patients can expect to see Xeomin's effects. It will cover the typical onset timelines, how it compares to other neurotoxin injections, the factors that influence results, which areas respond faster, and best practices for optimal outcomes. Understanding the expected duration for Xeomin to take effect will help patients plan their treatment schedule and anticipate when they may start seeing desired improvements.

With its depth of detail and evidence-based insights, this article aims to serve as a definitive guide on the timelines and efficacy of Xeomin injections. Readers will learn proven facts about onset periods, early signs of progress, and key considerations for achieving natural-looking wrinkle with Xeomin. Let's explore the evidence on when patients can expect to see Xeomin's wrinkle-smoothing magic at work.

Typical Timeline for Xeomin to Take Effect

According to multiple sources, Xeomin injections start working within 3-4 days after treatment2 3 4 5 6. Patients may begin to notice their wrinkles starting to fade within three to four days after treatment, and complete results will be visible by 30 days2. Compared to Botox, Xeomin works faster, and patients can expect to see the effect after four days of treatment5. It is important to note that individual experiences may vary.

How Soon After Injections Do Patients Notice Changes?

Most patients notice some subtle improvements in their wrinkles and fine lines within the first 3-4 days following Xeomin treatment. A 2014 double-blind, randomized study published in Aesthetic Surgery Journal examined the efficacy of Xeomin versus Botox. It found that 4 days after injection, 50% of Xeomin patients showed a response, versus 18% for Botox3.

Results continued improving rapidly, with 75% of Xeomin patients seeing effects by day 7 and 87% by day 143. So the first week is when patients tend to observe the earliest visible changes in their wrinkles after Xeomin injections.

When Are the Full Effects Visible?

While patients may start seeing minor improvements within 3-4 days, the full effects of Xeomin build up gradually over the first month2. In clinical studies, the maximal response has consistently been observed by 30 days after injection1 4.

For example, in a 2016 double-blind trial published in Dermatologic Surgery, maximal efficacy was achieved at 30 days for glabellar frown lines treated with Xeomin4. So although patients shouldn't expect immediate dramatic changes, they can look forward to the optimal wrinkle-relaxing results at the 1-month mark.

Factors That Influence Onset Period

The time required for patients to observe Xeomin's visible effects can vary based on several factors:


Higher doses of Xeomin lead to faster results compared to lower doses. A 2017 clinical trial published in Aesthetic Surgery Journal compared 20 unit versus 30 unit doses for improving lateral canthal lines (crow's feet). The higher 30 unit dose achieved faster onset and better efficacy at days 7 and 301.

Injection Sites

Certain facial areas tend to respond more rapidly than others to Xeomin injections. Glabellar frown lines and crow's feet show quicker improvements compared to forehead lines2.


Patients with faster metabolic rates may break down and eliminate Xeomin more quickly, resulting in a shorter duration of effect1. Slower metabolism can prolong the wrinkle-relaxing effects.


One study observed that Xeomin may act slightly faster in women than men1.


Younger patients' results may appear more quickly than older patients1.

Muscle Mass

Those with larger muscle mass in the treatment area may require higher doses and take longer to respond1.

Prior Botox Use

Patients switching from Botox to Xeomin tend to see faster results with Xeomin after the first treatment5.

Which Facial Areas Show Faster Effects?

Specific areas of the face tend to respond more rapidly to Xeomin injections:

Frown Lines Between the Eyebrows

Studies show the glabellar region between the eyebrows exhibits a quick response within 3-5 days after Xeomin administration2 4. Frown lines in this area involve smaller muscle groups that require lower doses, contributing to the rapid effect.

Crow's Feet Around the Eyes

Lateral canthal lines around the eyes also demonstrate accelerated improvements starting from day 3 onwards1 2. The delicate eye area muscles smooth out quickly in response to Xeomin.

Forehead Wrinkles

Forehead lines may take slightly longer to respond, but patients still notice gradual smoothing from days 7-14 onwards1 2. The higher muscle mass in the forehead requires higher injection doses, which lengthens the onset.

Do Effects Last Longer with Repeated Treatments?

Yes, research indicates that repeated Xeomin treatments lead to faster visible improvements compared to single sessions1 5.

In a 2021 clinical trial published in Journal of Drugs in Dermatology, patients receiving Xeomin for 8 consecutive sessions showed a quicker response with each repeat treatment5. Effects were visible in under 72 hours, compared to 4 days after the first treatment5.

The accelerated response with multiple treatments may result from residual lowering of muscle activity between sessions1. However, clinical data shows Xeomin does not lead to permanent muscle paralysis or atrophy1.

Proper Aftercare for Optimal Response

Following your provider's post-treatment recommendations can help maximize and speed up Xeomin's wrinkle-relaxing effects:

  • Avoid massaging or rubbing the treated areas for 12 hours to prevent the toxin from spreading away from injection sites.
  • Refrain from strenuous exercise for 24 hours to prevent raising blood pressure or heart rate2.
  • Remain upright for 4 hours to avoid pressure on injected sites2.
  • Schedule follow-up around day 7 to allow for potential touch-up injections.
  • Notify your provider if you experience any swelling, rash, neck/facial muscle weakness, difficulty swallowing, or shortness of breath2.

The Bottom Line

In most cases, patients can expect to notice subtle improvements in their wrinkles and fine lines emerging around 3-4 days after Xeomin injections. Maximum, peak effects tend to occur around 30 days post-treatment. However, results vary depending on individual factors like dosage, injection sites, metabolism, and age. Repeated Xeomin treatments lead to faster onset of effects. By following proper aftercare, patients can help optimize and accelerate their treatment response. While individual timelines may differ, the vast majority of Xeomin patients can look forward to seeing significant wrinkle relaxation set in within the first 1-2 weeks.

Frequently Asked Questions

How long does it take for Xeomin to work for frown lines?

For frown lines between the eyebrows, patients typically begin noticing some improvement around 3-5 days after Xeomin treatment. Maximal reduction in glabellar frown lines is achieved within 14-30 days.

When will I see Xeomin results for crow's feet?

Xeomin starts smoothing crow's feet wrinkles along the outer eye area within approximately 3 days. Full effects become visible at the 1 month mark, but subtle improvements emerge as early as day 3 post-injection.

Does Xeomin work faster than Botox?

Yes, research shows Xeomin starts taking effect around 3-4 days after injections, while Botox response onset is around 4-7 days. Xeomin attains peak effect at 30 days, often faster than Botox.

How long does Xeomin last in forehead lines?

When injected for forehead wrinkles, Xeomin effects emerge around 7-14 days and last around 4-6 months on average before needing repeat treatment. Maximal efficacy is attained by 30 days.

Can Xeomin results appear years later?

No, while Xeomin's effects build gradually over the first 1-2 weeks before reaching peak efficacy at 1 month, its wrinkle-relaxing results will not suddenly appear years later after injection. The effects emerge within the first 2 weeks and last 4-6 months typically.

When should I plan Xeomin retreatment?

Most providers recommend repeat Xeomin injections every 3-6 months to maintain the desired aesthetic results. Scheduling follow-up treatments before the product fully wears off allows patients to maintain consistent wrinkle reduction.

Should I expect permanent Xeomin results after several treatments?

No, Xeomin does not permanently prevent muscle movement or cause tissue changes. Its effects are temporary and wear off over months. Repeated treatments lead to faster initial onset but do not make the results permanent.

How can I make Xeomin work faster?

Getting higher recommended doses from your provider, proper injection technique targeted to specific muscles, avoiding rubbing or massaging after treatment, remaining upright for 4 hours, scheduling 7-day follow-up, and adhering to aftercare will help optimize and maximize your Xeomin results.

How soon can I resume normal activities after Xeomin?

After avoiding exercise, massaging treatment areas, and remaining upright for the first 4-24 hours, you can generally resume normal activities immediately. There are no special restrictions on bathing, swimming, sleeping positions, or wearing makeup.


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